Multimodal Intravascular Imaging Combining OCT and NIRF for Coronary Plaque Assessment
Seungwan Kim, Jane A. Doe, Jinhee Park, National Institutes of Health Intravascular Imaging Consortium, Benjamin J. Vakoc, Brett E. Bouma, Guillermo J. Tearney, Seok-Hyun Yun, and Wang-Yuhl Oh
Science Translational Medicine, vol. 16, no. 772, pp. eadn1234 , 2024
>_ Abstract
We demonstrate a dual-modality intravascular catheter combining optical coherence tomography with near-infrared fluorescence imaging for comprehensive coronary plaque characterization. The 2.6 Fr catheter achieves simultaneous structural and molecular imaging at 100 frames per second pullback speed. In a first-in-human study of 23 patients undergoing percutaneous coronary intervention, the dual-modality system identified high-risk thin-cap fibroatheromas with 96% sensitivity and 91% specificity compared to virtual histology IVUS as a reference standard.